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bizarre Drugs Are Good and These People Prove It (comp)

I never understood this behavior. I understand that each of us is different. However, at a fundamental level, a chemical reaction is a chemical reaction. Is human physiology really so unique amongst individuals that the exact same substance introduced to two different people can create a vastly different experience? I'm certain that for every one of these people, there are 10 who had no issues. I wonder what causes that? Aside from frequency of use and tolerance?
 
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