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Pa. researchers use toxic tomb fungus to attack cancer cells

It's known as the deadly fungus credited with killing the archaeologists who opened the tomb of King Tut.

Now, University of Pennsylvania researchers say they've transformed it into a promising treatment for cancer.

Aspergillus flavus is a toxic yellow-spored fungus that likely entered and flourished in the lungs of the crew members who untombed the Egyptian pharaoh in the 1920s.

After isolating a new class of molecules from the fungus, researchers were able to, in short, modify their chemical outlook.

When mixed with human cancer cells, those modified cells demonstrated medical potential, as two of the four variants had potent effects against leukemia cells, preventing them from dividing.

The next step is to test those compounds in animals with the hope of one day moving to human clinical trials.

“Nature has given us this incredible pharmacy,” said Sherry Gao, an associate professor in Chemical and Biomolecular Engineering and Bioengineering at the University of Pennsylvania. “It’s up to us to uncover its secrets. As engineers, we’re excited to keep exploring, learning from nature and using that knowledge to design better solutions."

You can read the full findings from Penn researchers here.

 
Almost every antimicrobial agents, like antibiotics, are produced by microbes. Eg penicillin from fungus or streptomycin from bacteria.

Rapamycin is made from a bacteria isolated on Easter Island, aka Rapa Nui which is how Rapamycin was named. It was initially going to be an antifungal medicine, but then was used to suppress immune systems in organ transplants after being studied. But now Rapamycin is being tested for its anti-ageing properties by inhibiting mTOR.

Microbes terraformed the planet, and we evolved from them. So those little friends hold the keys to many health factors, including treatments for cancer and other chronic illnesses. Lions Mane fungi has some interesting neuro-regenerative properties as well as immune boosting effects that augment cancer therapies.

This is also why we need to care for our microbiome.
 
Almost every antimicrobial agents, like antibiotics, are produced by microbes. Eg penicillin from fungus or streptomycin from bacteria.

Rapamycin is made from a bacteria isolated on Easter Island, aka Rapa Nui which is how Rapamycin was named. It was initially going to be an antifungal medicine, but then was used to suppress immune systems in organ transplants after being studied. But now Rapamycin is being tested for its anti-ageing properties by inhibiting mTOR.

Microbes terraformed the planet, and we evolved from them. So those little friends hold the keys to many health factors, including treatments for cancer and other chronic illnesses. Lions Mane fungi has some interesting neuro-regenerative properties as well as immune boosting effects that augment cancer therapies.

This is also why we need to care for our microbiome.
There's no place like microbiome.
Keep Clicking Those Ruby GIF Slippers – CogDogBlog
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